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At the 2017 American Society of Clinical Oncology (ASCO) Annual Meeting, Boehringer Ingelheim presented overall survival analysis of the LUME-Meso trial, results of the Phase III LUX-Head and Neck 2 trial and results of the first-in-man Phase I trial of the novel BET inhibitor, BI894999*.
For more details, please see below.
The full ASCO 2017 programme can be found here.
Phase I first-in-man trial of a novel bromodomain and extra-terminal domain (BET) inhibitor (BI 894999) in patients (Pts) with advanced solid tumors. (Abstract 2504)
LUX-head and neck 2: Randomized, double-blind, placebo-controlled, phase III trial of afatinib** as adjuvant therapy after chemoradiation (CRT) in primary unresected, high/intermediate-risk, squamous cell cancer of the head and neck (HNSCC) patients (pts). (Abstract 6001)
Mature overall survival (OS) results from the LUME-Meso study of nintedanib¶ (N) + pemetrexed/cisplatin (PEM/CIS) vs placebo (P) + PEM/CIS in chemo-naïve patients (pts) with malignant pleural mesothelioma (MPM) (Abstract 8506)
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*This is an investigational compound and has not been approved. Its safety and efficacy have not been established.
**Afatinib is approved in more than 70 markets including the EU, Japan, Taiwan, and Canada under the brand name GIOTRIF®, in the US under the brand name GILOTRIF® and in India under the brand name Xovoltib®; for the full list please see here. Registration conditions differ internationally; please refer to locally approved prescribing information.
¶Nintedanib is approved in the EU under the brand name VARGATEF® for use in combination with docetaxel in adult patients with locally advanced, metastatic or locally recurrent NSCLC of adenocarcinoma tumour histology after first-line chemotherapy. For the full list of country-specific information please click here. Nintedanib is not approved in other oncology indications.
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